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Understanding 9/11Fatty acid synthesis is an iterative process which begins with the transfer of an acetyl moiety from acetyl-CoA to fatty acid synthase, following this activation, carbons are added to the growing chain in the form of malonyl-CoA
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This image is part of a series that was created for an open textbook, Cell Biology, Genetics and Biochemistry for PreClinical Students. The textbook will be available Late 2021.
Preferred citation:
Kindred Grey (2021). "Fatty acid synthesis is an iterative process which begins with the transfer of an acetyl moiety from acetyl-CoA to fatty acid synthase, following this activation, carbons are added to the growing chain in the form of malonyl-CoA." CC BY 4.0.
Alternative text:
(n+2) fatty acyl-ACP solid arrow with text 7 cycles to fatty acyl-ACP arrow losing ACP and CO2 with enzyme β-ketoacyl-ACP synthase to β-ketoacyl-ACP arrow with enzyme β-ketoacyl-ACP reductase and NADPH arrow NADP+ to β-hydroxyacyl-ACP arrow losing H2O with enzyme β-hydroxyacyl-ACP dehydratase to trans-enoyl-ACP arrow with enzyme Enoyl-ACP reductase and NADPH arrow NADP+ to (n+2) fatty acyl-ACP. (n+2) fatty acyl-ACP dotted arrow Palmitate (C16) arrow with enzyme long-chain fatty acyl-CoA synthase and ATP arrow AMP, addition of CoA, loss of PPi to palmitoyl-CoA.Reviews
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